July 16, 2018
NRG Oncology Broadcast archives are accessible from our website at any time. Please bookmark  this link  for your convenience.

 

Over 1,200 individuals attended the NRG Oncology Summer 2018 Meeting at the Philadelphia, PA Downtown Marriott Hotel. Read More

The NRG Oncology publications page on the website has moved. Read more

AMENDMENTS AND UPDATES
BREAST
NRG-BR003: Attention! Sites in Canada!Activation Instructions for Amendment #1 (version date December 18, 2017) for sites participating in Canada are posted to the BR003 page on the CTSU website.

GYNECOLOGIC
NRG-GY004: Action Letter - Amendment 7; Version date: June 22, 2018 (posted on CTSU).

OTHER PROTOCOL NOTICES
VTOC Training
The VTOC Webinar Training Series schedule and registration is available for NRG Oncology Research Associates working on RTOG 0924, RTOG 0920, NRG-HN001, NRG-HN002, NRG-CC003, and NRG-CC004. Space is limited so register now and reserve your seat.  The next webinar training is scheduled for August 15, 2018.

 

DRUG SAFETY UPDATES AND INVESTIGATOR’S BROCHURE (IB) NOTICES
Safety updates and IB notices have been issued for the following studies: 

DRUG NAME

PROTOCOL

WEBSITE FOR SAFETY REPORTS

INVESTIGATOR'S BROCHURE (IB)*

Durvalumab

NRG-HN004

CTSU

 

Ipilimumab

NRG-BN002

NRG-GY003

NRG

NRG

 

Nivolumab

 

NRG-BN002

NRG-GY002

NRG-GY003

NRG

NRG

NRG

X

X

X

Olaparib

NRG-GY004

NRG-GY005

NSABP B-55

CTSU

CTSU

CTSU

 

Pembrolizumab

NRG-HN003

NRG

X

 

*The current version of the Investigator Brochure Documents for Division of Cancer Treatment and Diagnosis (DCTD), National Cancer Institute (NCI)-sponsored trials are available for access via the Cancer Therapy Evaluation Program (CTEP) Online Agent Order Processing (OAOP) website ( https://ctepcore.nci.nih.gov/OAOP/). Log-in using your Identity and Access Management (IAM) username and password credentials and provide the requested information to access the document.

Every site principal investigator is responsible for reviewing this document. The Investigator Brochure is for use by the site principal investigator and any study personnel under his/her supervision who need to know the contents for the conduct of a clinical trial, including Institutional Review Board(s) or Independent Ethics Committee(s).



NRG Oncology Semiannual Meeting in Philadelphia
The NRG Oncology Summer 2018 Meeting convened last week at the Philadelphia, PA Downtown Marriott Hotel. Over 1200 individuals attended.  It was standing room only at the NRG Digital Health Symposium on Thursday as well as the special workshop on Social Media on Friday. A session on Financial Toxicity highlighted the barriers faced in cancer care and the individuals ability to pay for care. Other highlights include the announcement of the preliminary scores on the NRG Oncology Operations Center and Statistical and Data Management Center renewal grants are in the “exceptional” range. Dr. D. Lawrence Wickerham, Deputy Group Chair for Membership and NCORP PI, was recognized at several sessions as this represented his last meeting prior to retiring at the end of the year.  Attendees also learned that NCORP Research Base and Community Site grant opportunities have been released and are due at the end of August of this year.  Attendees highlighted information from the many scientific sessions on Twitter using the hashtag #NRG18.

NEWS from the CTSU
Investigational Agent Related Forms – Please note that over the next several weeks, the CTSU will change the location of the materials and links to order Investigational Brochures (IBs) from the Site Registration subtab to the Pharmacy subtab. This means that moving forward, all materials and links related to study agents, be that for obtaining IBs or the agents themselves, will be posted together in one location. This includes the link to the Pharmaceutical Management Branch’s (PMB) Online Agent Order Processing (OAOP) application (used to order agents and IBs from PMB), as well as any forms needed to order IBs or agents from non-PMB sources (as applicable). This update applies to protocols that are open cross-network and for which the CTSU posts the Lead Protocol Organization (LPO) documents. For protocols that only have CIRB documents and/or funding information posted, please refer to the LPO website for agent information.

NCI and PCORI’s Evaluation of Proton Therapy Trials
A recent publication in the Journal of Clinical Oncology (JCO) from the National Cancer Institute (NCI) and the Patient-Centered Outcomes Research Institute (PCORI) addresses the importance of proton therapy trials. This publication also weighs in on the barriers that affect patient enrollment on proton therapy trials, such as insurance coverage, and details some actionable solutions to these barriers. Read more


 

NEW LOCATION ON WEBSITE
Please note that the NRG Oncology Publications tab on the website has relocated. You can now find the publications section under the Clinical Trials tab of the website:  nrgoncology.org/Clinical-Trials/Publications 

NRG Oncology is pleased to report the scientific articles and abstracts that have appeared or have been presented during the previous week. This publications report includes links, when available, to the article, PubMed abstract, or association abstract.

JOURNAL ARTICLES
Bell EH, Zhang P, Fisher BJ, Macdonald DR, McElroy JP, Lesser GJ, Fleming J, Chakraborty AR, Liu Z, Becker AP, Fabian D, Aldape KD, Ashby LS, Werner-Wasik M, Walker EM, Bahary JP, Kwok Y, Yu HM, Laack NN, Schultz CJ, Gray HJ, Robins HI, Mehta MP, Chakravarti A. Association of MGMT Promoter Methylation Status With Survival Outcomes in Patients With High-Risk Glioma Treated With Radiotherapy and Temozolomide: An Analysis From the NRG Oncology/RTOG 0424 Trial. JAMA Oncol. 2018 Jun 28. doi: 10.1001/jamaoncol.2018.1977. [Epub ahead of print] PubMed PMID: 29955793   Read more

Klopp AH, Yeung AR, Deshmukh S, Gil KM, Wenzel L, Westin SN, Gifford K, Gaffney DK, Small W Jr, Thompson S, Doncals DE, Cantuaria GHC, Yaremko BP, Chang A, Kundapur V, Mohan DS, Haas ML, Kim YB, Ferguson CL, Pugh SL, Kachnic LA, Bruner DW. Patient-Reported Toxicity During Pelvic Intensity-Modulated Radiation Therapy: NRG Oncology-RTOG 1203. J Clin Oncol. 2018 Jul 10:JCO2017774273. doi: 10.1200/JCO.2017.77.4273. [Epub ahead of print] PubMed PMID: 29989857.   Read more

Rogers L, Zhang P, Vogelbaum MA, Perry A, Ashby LS, Modi JM, Alleman AM, Galvin J, Brachman D, Jenrette JM, De Groot J, Bovi JA, Werner-Wasik M, Knisely JPS, Mehta MP. Intermediate-risk meningioma: initial outcomes from NRG Oncology RTOG 0539. J Neurosurg. 2018 Jul;129(1):35-47. doi: 10.3171/2016.11.JNS161170. Epub 2017 Oct 6. PubMed PMID: 28984517; PubMed Central PMCID: PMC5889346.  Read more

Sparano JA, Gray RJ, Makower DF, Pritchard KI, Albain KS, Hayes DF, Geyer CE Jr, Dees EC, Goetz MP, Olson JA Jr, Lively T, Badve SS, Saphner TJ, Wagner LI,Whelan TJ, Ellis MJ, Paik S, Wood WC, Ravdin PM, Keane MM, Gomez Moreno HL, Reddy PS, Goggins TF, Mayer IA, Brufsky AM, Toppmeyer DL, Kaklamani VG, Berenberg JL, Abrams J, Sledge GW Jr. Adjuvant Chemotherapy Guided by a 21-Gene Expression Assay in Breast Cancer. N Engl J Med. 2018 Jul 12;379(2):111-121. doi: 10.1056/NEJMoa1804710. Epub 2018 Jun 3. PubMed PMID: 29860917. Read more

Spratt DE, Dai DLY, Den RB, Troncoso P, Yousefi K, Ross AE, Schaeffer EM, Haddad Z, Davicioni E, Mehra R, Morgan TM, Rayford W, Abdollah F, Trabulsi E, Achim M, Tapia ELN, Guerrero M, Karnes RJ, Dicker AP, Hurwitz MA, Nguyen PL, Feng FFY, Freedland SJ, Davis JW. Performance of a Prostate Cancer Genomic Classifier in Predicting Metastasis in Men with Prostate-specific Antigen Persistence Postprostatectomy. Eur Urol. 2018 Jul;74(1):107-114. doi: 10.1016/j.eururo.2017.11.024. Epub 2017 Dec 10. PubMed PMID: 29233664.   Read more

PUBLICATIONS REMINDERS
Please note the following upcoming meeting and abstract submission deadline dates

Upcoming Meetings

ASCO Research Community Forum Annual Meeting; Sep 23-24, 2018; Washington, DC

American Association of Physicists in Medicine (AAPM); Jul 29 - Aug 2, 2018; Nashville, TN

College of American Pathologists (CAP); Oct 20–24, 2018; Chicago, IL

European Society for Medical Oncology (ESMO); Oct 19-23, 2018; Munich, Germany

Upcoming Abstract Submission Deadlines
American Society for Radiation Oncology (ASTRO); Oct 21-24, 2018; San Antonio, TX; Late-breaking submission site opens Jul 18, 2018; Late-breaking submission site closes Aug 1, 2018

European Society for Medical Oncology (ESMO); Oct 19-23, 2018; Munich, Germany; Late-breaking Sep 17, 2018

Society of Clinical Research (SOCRA); Sep 28-30, 2018; New Orleans, LA; meeting abstracts submission deadline July 20, 2018

NRG Oncology is proud to be an active participant of #CancerMoonShot.
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