NRG-CC003 - Protocol Reopening


Effective immediately, NRG-CC003, “A Randomized Phase II/III Trial of Prophylactic Cranial Irradiation with or without Hippocampal Avoidance for Small Cell Lung Cancer”, has been reopened to patient accrual.

The analysis of intracranial relapse rate of hippocampal avoidance during whole brain radiation (HA-PCI) compared to PCI, for the Phase II component of the study, has been completed. The study is now reopened to the Phase III component to determine whether HA-PCI reduces the likelihood of 6-month deterioration from baseline.

The protocol documents are located on the CTSU website.

Please distribute this information to the appropriate personnel at participating affiliate/NCORP component institutions.

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